5.Treatments of vestibular schwannomas associated with neurofibromatosis type 2
نویسندگان
چکیده
منابع مشابه
Bevacizumab induces regression of vestibular schwannomas in patients with neurofibromatosis type 2.
Bilateral vestibular schwannomas are the hallmark of neurofibromatosis type 2 (NF2), and these tumors impair hearing and frequently lead to deafness. Neurosurgical intervention, the only established treatment, often damages the vestibular nerve. We report 2 cases in which treatment with bevacizumab (for 3 months in one case and 6 months in the other) induced regression of progressive vestibular...
متن کاملA neurofibromatosis type 2 case with vestibular, trigeminal and facial schwannomas: Magnetic resonance imaging findings
Neurofibromatosis type 2 is characterized by the development of multiple nervous system tumors. This disorder is also called multiple inherited schwannomas, meningiomas, and ependymomas syndrome. In this report, we discuss the magnetic resonance imaging findings in a patient with Neurofibromatosis type 2 who had right and left vestibular and trigeminal schwannomas, unilateral facial schwannoma,...
متن کاملMutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas.
Schwannomas are common tumors of the nervous system and are frequently found in patients with neurofibromatosis (NF) 2. Although loss of heterozygosity in NF2 tumors suggests that the NF2 gene functions as a tumor suppressor gene, the NF2 gene shows amino acid sequence homology to structural proteins in one of which dominantly acting mutations have been described. We performed a mutational anal...
متن کاملGamma Knife radiosurgery for treatment of growing vestibular schwannomas in patients with neurofibromatosis Type 2: a matched cohort study with sporadic vestibular schwannomas.
OBJECTIVE Neurofibromatosis Type 2 (NF2) is a tumor syndrome characterized by an autosomal dominant pattern of inheritance. The hallmark of NF2 is the development of bilateral vestibular schwannomas (VSs), generally by 30 years of age. One of the first-line treatment options for small to medium-large VSs is radiosurgery. Although radiosurgery shows excellent results in sporadic VS, its use in N...
متن کاملMultiple synchronous sites of origin of vestibular schwannomas in neurofibromatosis Type 2
BACKGROUND Neurofibromatosis Type 2 (NF2) is a dominantly inherited tumour syndrome with a phenotype which includes bilateral vestibular (eighth cranial nerve) schwannomas. Conventional thinking suggests that these tumours originate at a single point along the superior division of the eighth nerve. METHODS High resolution MRI was performed in children genetically proven to have NF2. The super...
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ژورنال
عنوان ژورنال: Japanese Journal of Neurosurgery
سال: 2003
ISSN: 0917-950X,2187-3100
DOI: 10.7887/jcns.12.271_1